The year 1605 CE in science and technology included many events, some of which are listed below.

See also: 1604 in science, other events of 1605, 1606 in science and the list of years in science.

Exploration

• France founds Port Royal in its North American colony of Acadia.

Births

• Simon Dezhnev, navigator
• Sir Thomas Browne, physician, encyclopedist

Deaths

• John Davis, explorer