The year 1601 CE in science and technology included many events, some of which are listed below.

See also: 1600 in science, other events of 1601, 1602 in science, and the list of years in science.

Exploration

• Olivier van Noort completes his circumnavigation of the world.

Mathematics

• Johannes Kepler is appointed imperial mathematician to the Hapsburg Empire.

Births

• August 20 - Pierre de Fermat, French mathematician.

Deaths

• Tycho Brahe, Danish astronomer.