The year 1543 in science and technology included many events, some of which are listed here.

Astronomy

Nicolaus Copernicus, De Revolutionibus Orbium Coelestium (On the Revolutions of the Heavenly Spheres), offered entirely abstract mathematical arguments for the existence of the heliocentric universe.

Births

Deaths

• May 24 - Nicolaus Copernicus (b. 1473 ), astronomer.