Events

• June 19 - Battle of Landriano - A French army in Italy under Marshal St. Pol is decisively defeated.
• November 6 - Shipwrecked Spanish conquistador Álvar Núñez Cabeza de Vaca becomes the first known European to set foot on Texas.
• Andrea Doria revolts against the French and establishes the independence of Genoa.
• Montenegro gains autonomy under Turk power.
• Maya people drive Spanish Conquistadors out of Yucatán.
• Spain takes direct control of Acapulco.
• Bubonic plague breaks out in England.
• Major outbreak of the sweating sickness in England, speads to much of the continent.
• St George's Chapel in Windsor Castle completed.
• Chateau Fontainebleau in France begun.
• Cardinal Wolsey founds a college at Ipswich.
• Michelangelo Buonarroti begins work on fortifications of Florence.
• Baldassare Castiglione publishes The Book of the Courtier.

Births

• January 7 - Jeanne d'Albret, Queen of Navarre (d. 1572)
• Paolo Boi , Italian chessmaster
• July 8 - Emmanuel Philibert, Duke of Savoy (+ 1580)
• October 4(?) - Francisco Guerrero, Spanish composer
• Akechi Mitsuhide, Japanese samurai and warlord

Deaths

• April 6 - Albrecht Dürer, German artist, writer and mathematician
• Giovanni da Verrazzano, explorer